Clinical Nutrition
Volume 22, Issue 5 , Pages 429-435 , October 2003

Genetics and nutrition

  • A Paoloni-Giacobino

      Affiliations

    • Division of Clinical Nutrition, Geneva University Hospital, Switzerland
  • ,
  • R Grimble

      Affiliations

    • Institute of Human Nutrition, School of Medicine, University of Southampton, UK
  • ,
  • C Pichard

      Affiliations

    • Division of Clinical Nutrition, Geneva University Hospital, Switzerland
    • Corresponding Author InformationCorrespondence to: CP, Division of Clinical Nutrition, Geneva University Hospital, 24 Micheli-du-Crest, 1211 Geneva

Received 15 April 2003 ,Accepted 15 April 2003.

References 

  1. Subramanian G, Adams M D, Venter J C, Broder S. Implications of the human genome for understanding human biology and medicine. JAMA 2001; 286: 2296–2307
  2. Jousse C, Bruhat A, Ferrara M, Fafournoux P. Evidence for multiple signaling pathways in the regulation of gene expression by amino acids in human cell lines. J Nutr 2000; 130: 1555–1560
  3. Bain P J, LeBlanc-Chaffin R, Chen H, Palii S S, Leach K M, Kilberg M S. The mechanism for transcriptional activation of the human ATA2 transporter gene by amino acid deprivation is different than that for asparagine synthetase. J Nutr 2002; 132: 3023–3029
  4. Schoonjans K, Brendel C, Mangelsdorf D, Auwerx J. Sterols and gene expression: control of affluence. Biochim Biophys Acta 2000; 1529: 114–125
  5. Ames B N. Micronutrientspreventcancer, delay aging. Toxicol Lett 1998; 102–103: 5–18.
  6. Sies H, Stahl W, Sundquist A R. Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids. Ann N Y Acad Sci 1992; 669: 7–20
  7. Duthie S J, Ma A, Ross M A, Collins A R. Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res 1996; 56: 1291–1295
  8. Collins A R, Olmedilla B, Southon S, Granado F, Duthie S J. Serum carotenoids and oxidative DNA damage in human lymphocytes. Carcinogenesis 1998; 19: 2159–2162
  9. Torbergsen A C, Collins A R. Recovery of human lymphocytes from oxidative DNA damage; the apparent enhancement of DNA repair by carotenoids is probably simply an antioxidant effect. Eur J Nutr 2000; 39: 80–85
  10. Peto R, Doll R, Buckley J D, Sporn M B. Can dietary beta-carotene materially reduce human cancer rates? Nature 1981; 290: 201–208
  11. Ziegler R G. A review of epidemiologic evidence that carotenoids reduce the risk of cancer. J Nutr 1989; 119: 116–122
  12. Hennekens C H, Buring J E, Manson J E et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. New Engl J Med 1996; 334: 1145–1149
  13. Omenn G S, Goodman G E, Thornquist M D et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. New Engl J Med 1996; 334: 1150–1155
  14. The Alpha-Tocopherol BCCPSG. The effect of vitamin E, beta carotene on the incidence of lung cancer and other cancers in male smokers. New Engl J Med 1994; 330: 1029–1035
  15. Bertram J S, Bortkiewicz H. Dietary carotenoids inhibit neoplastic transformation and modulate gene expression in mouse and human cells. Am J Clin Nutr 1995; 62: 1327–1336
  16. Obermuller-Jevic U C, Francz P I, Frank J, Flaccus A, Biesalski H K. Enhancement of the UVA induction of haem oxygenase-1 expression by beta-carotene in human skin fibroblasts. FEBS Lett 1999; 460: 212–216
  17. Nagpal S, Chandraratna R A. Vitamin A and regulation of gene expression. Curr Opin Clin Nutr Metab Care 1998; 1: 341–346
  18. Fenech M. Recommended dietary allowances (RDAs) for genomic stability. Mutat Res 2001; 480–481: 51–54
  19. Zingg J M, Jones P A. Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis 1997; 18: 869–882
  20. Ames B N. Cancerprevention, diet: help from single nucleotide polymorphisms. Proc Nat Acad Sci USA 1999; 96: 12216–12218
  21. Gulati S, Brody L C, Banerjee R. Posttranscriptional regulation of mammalian methionine synthase by B12. Biochim Biophys Res Commun 1999; 259: 436–442
  22. Jhaveri M S, Wagner C, Trepel J B. Impact of extracellular folate levels on global gene expression. Mol Pharmacol 2001; 60: 1288–1295
  23. Halliwell B. VitaminC, genomic stability. Mutat Res 2001; 475: 29–35
  24. Halliwell B. Vitamin C: poison, prophylactic or panacea? Trends Biochem Sci 1999; 24: 255–259
  25. Rehman A, Collis C S, Yang M et al. The effects of iron and vitamin C co-supplementation on oxidative damage to DNA in healthy volunteers. Biochim Biophys Res Commun 1998; 246.
  26. Catani M V, Rossi A, Costanzo A et al. Induction of gene expression via activator protein-1 in the ascorbate protection against UV-induced damage. Biochem J 2001; 356: 77–85
  27. Sowers M, Lachance L. Vitamins and arthritis. The roles of vitamins A, C, D, and E. Rheum Dis Clin North Am 1999; 25: 315–332
  28. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999; 69: 842–856
  29. Chatterjee M. Vitamin D, genomic stability. Mutat Res 2001; 475: 69–87
  30. Wang S H, Koenig R J, Giordano T J, Myc A, Thompson N W, Baker J R J. 1 alpha, 25-dihydroxyvitamin D3 up-regulates Bcl-2 expression and protects normal human thyrocytes from programmed cell death. Endocrinology 1999; 140: 1649–1656
  31. Brelvi Z S, Studzinski G P. Inhibition of DNA synthesis by an inducer of differentiation of leukemic cells, 1 alpha, 25 dihydroxy vitamin D3, precedes down regulation of the c-myc gene. J Cell Physiol 1986; 128: 171–179
  32. Kuroki Y, Shiozawa S, Kano J, Chihara K. Competition between c-fos and 1, 25(OH)2 vitamin D3 in the transcriptional control of type I collagen synthesis in MC3T3-E1 osteoblastic cells. J Cell Physiol 1995; 164: 459–464
  33. Li Y C, Kong J, Wei M, Chen Z F, Liu S Q, Cao L P. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002; 110: 229–238
  34. Farach-Carson M C, Xu Y. Microarray detection of gene expression changes induced by 1,25(OH)(2)D(3) and a Ca(2+) influx-activating analog in osteoblastic ROS 17/2.8 cells. Steroids 2002; 67: 467–470
  35. Feki M, Souissi M, Mebazaa A. Vitamin E: structure, metabolism, and functions. Ann Med Interne 2001; 152: 384–391
  36. Claycombe K J, Meydani S N. Vitamin E and genome stability. Mutat Res 2001; 475: 37–44
  37. Brigelius-Flohe R, Kelly F J, Salonen J T, Neuzil J, Zingg J M, Azzi A. The European perspective on vitamin E: current knowledge and future research. Am J Clin Nutr 2002; 76: 703–716
  38. Aratri E, Spycher S E, Breyer I, Azzi A. Modulation of alpha-tropomyosin expression by alpha-tocopherol in rat vascular smooth muscle cells. FEBS Lett 1999; 447: 91–94
  39. Zhao B, Yu W, Qian M et al. Involvement of activator protein-1 (AP-1) in induction of apoptosis by vitamin E succinate in human breast cancer cells. Mol Carcinog 1997; 19: 180–190
  40. Calabrese V, Scapagnini G, Catalano C et al. Regulation of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: role of vitamin E. Int J Tissue React 2001; 23: 127–135
  41. Li-Weber M, Giaisi M, Treiber M K, Krammer P H. Vitamin E inhibits IL-4 gene expression in peripheral blood T cells. Eur J Immunol 2002; 32: 2401–2408
  42. Ricciarelli R, Maroni P, Ozer N, Zingg J M, Azzi A. Age-dependent increase of collagenase expression can be reduced by alpha-tocopherol via protein kinase C inhibition. Free Rad Biol Med 1999; 27: 729–737
  43. Jefferson L S, Kimball S R. Amino acid regulation of gene expression. J Nutr 2001; 131: 2460–2466
  44. Wang X Z, Lawson B, Brewer J W et al. Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Mol Cell Biol 1996; 16: 4273–4280
  45. Bruhat A, Jousse C, Wang X Z, Ron D, Ferrara M, Fafournoux P. Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels. J Biol Chem 1997; 272: 17588–17593
  46. Varga J, Li L, Mauviel A, Jeffrey J, Jimenez S A. l-Tryptophan in supraphysiologic concentrations stimulates collagenase gene expression in human skin fibroblasts. Lab Invest 1994; 70: 183–191
  47. Escher P, Wahli W. Peroxisome proliferator-activated receptors: insight into multiple cellular functions. Mutat Res 2000; 448: 121–138
  48. Berger J, Moller D E. The mechanisms of action of PPARs. Ann Rev Med 2002; 53: 409–435
  49. Motojima K, Passilly P, Peters J M, Gonzalez F J, Latruffe N. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. J Biol Chem 1998; 273: 16710–16714
  50. Schoonjans K, Watanabe M, Suzuki H et al. Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J Biol Chem 1995; 270: 19269–19276
  51. Tugwood J D, Issemann I, Anderson R G, Bundell K R, McPheat W L, Green S. The mouse peroxisome proliferator activated receptor recognizes a response element in the 5’ flanking sequence of the rat acyl CoA oxidase gene. EMBO J 1992; 11: 433–439
  52. Marcus S L, Miyata K S, Zhang B S S, Rachubinski R A, Capone J P. Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression. Proc Nat Acad Sci USA 1993; 90: 5723–5727
  53. Zhang B, Marcus S L, Miyata K S, Subramani S, Capone J P, Rachubinski R A. Characterization of protein-DNA interactions within the peroxisome proliferator-responsive element of the rat hydratase-dehydrogenase gene. J Biol Chem 1993; 268: 12939–12945
  54. Tontonoz P, Hu E, Spiegelman B M. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994; 79: 1147–1156
  55. Tontonoz P, Hu E, Devine J, Beale E G, Spiegelman B M. PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol 1995; 15: 351–357
  56. Schoonjans K, Peinado-Onsurbe J, Lefebvre A M et al. PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J 1996; 15: 5336–5348
  57. Kelly L J, Vicario P P, Thompson G M et al. Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression. Endocrinology 1998; 139: 4920–4927
  58. Hofmann C, Lorenz K, Braithwaite S S et al. Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance. Endocrinology 1994; 134: 264–270
  59. Kallen C B, Lazar M A. Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes. Proc Nat Acad Sci USA 1996; 93: 5793–5796
  60. Vaulont S, Vasseur-Cognet M, Kahn A. Glucose regulation of gene transcription. J Biol Chem 2000; 275: 31555–31558
  61. Decaux J F, B.A, Kahn A. Regulation of the expression of the l-type pyruvate kinase gene in adult rat hepatocytes in primary culture. J Biol Chem 1989; 264: 11584–11590
  62. Marie S, Diaz-Guerra M J, Miquerol L, Kahn A, Iynedjian P. The pyruvate kinase gene as a model for studies of glucose-dependent regulation of gene expression in the endocrine pancreatic beta-cell type. J Biol Chem 1993; 268: 23881–23890
  63. Brun T, Roche E, Kim K H, Prentki M. Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic beta-cell line (INS-1). J Biol Chem 1993; 268: 18905–18911
  64. Foufelle F, Gouhot B, Pegorier J P, Perdereau D, Girard J, Ferre P. Glucose stimulation of lipogenic enzyme gene expression in cultured white adipose tissue. A role for glucose 6-phosphate. J Biol Chem 1992; 267: 20543–20546
  65. Prip-Buus C, Perdereau D, Foufelle F, Maury J, Ferre P, Girard J. Induction of fatty-acid-synthase gene expression by glucose in primary culture of rat hepatocytes. Dependency upon glucokinase activity. Eur J Biochem 1995; 230: 309–315
  66. Foufelle F, Ferre P, 377–391. BJ. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J 2002; 366: 377–391
  67. Lockhart D J, Winzeler E A. Genomics, gene expression and DNA arrays. Nature 2000; 405: 827–836
  68. Hirschi K D, Kreps J A, Hirschi K K. Molecular approaches to studying nutrient metabolism and function: an array of possibilities. J Nutr 2001; 131: 1605S–1609S
  69. Blanchard R K, Moore J B, Green C L, Cousins R J. Modulation of intestinal gene expression by dietary zinc status: effectiveness of cDNA arrays for expression profiling of a single nutrient deficiency. Proc Nat Acad Sci USA 2001; 98: 13507–13513
  70. Sachidanandam R, D W, Schmidt S C et al. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 2001; 409: 928–933
  71. Ueland P M, Hustad S, Schneede J, Refsum H, Vollset S E. Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci 2001; 22: 195–201
  72. Schwahn B, Rozen R. Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences. Am J Pharmacogenomics 2001; 1: 189–201
  73. Talmud P J, Waterworth D M. In-vivo and in-vitro nutrient–gene interactions. Curr Opin Lipidol 2000; 11: 31–36
  74. Melton D W. The use of gene targeting to develop animal models for human genetic diseases. Biochem Soc Trans 1990; 18: 1035–1039
  75. Carter CP, Howles PN, Hui DY. Genetic variation in cholesterol absorption efficiency among inbred strains of mice. J Nutr 1997; 127: 1344–1348
  76. Howles P N, Carter C P, Hui D Y. Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice. J Biol Chem 1996; 271: 7196–7202
  77. Meiner V L, Cases S, Myers H M et al. Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals. Proc Nat Acad Sci USA 1996; 93: 14041–14046

PII: S0261-5614(03)00064-5

doi: 10.1016/S0261-5614(03)00064-5

Clinical Nutrition
Volume 22, Issue 5 , Pages 429-435 , October 2003