Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality

  • Author Footnotes
    e Present address: Department of Food Science and Nutrition, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, PR China.
    Tao Huang
    Footnotes
    e Present address: Department of Food Science and Nutrition, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, PR China.
    Affiliations
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, PR China

    APCNS Centre of Nutrition and Food Safety, Hangzhou, PR China
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  • Ying Chen
    Affiliations
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, PR China

    APCNS Centre of Nutrition and Food Safety, Hangzhou, PR China
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  • Bin Yang
    Affiliations
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, PR China

    APCNS Centre of Nutrition and Food Safety, Hangzhou, PR China
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  • Jing Yang
    Affiliations
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, PR China

    APCNS Centre of Nutrition and Food Safety, Hangzhou, PR China
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  • Mark L. Wahlqvist
    Affiliations
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, PR China

    APCNS Centre of Nutrition and Food Safety, Hangzhou, PR China

    National Health Research Institutes, Zhunan, Taiwan

    Monash Asia Institute, Monash University, Melbourne, Australia
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  • Duo Li
    Correspondence
    Corresponding author. Department of Food Science and Nutrition, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, PR China. Tel./fax: +86 571 86971024.
    Affiliations
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, PR China

    APCNS Centre of Nutrition and Food Safety, Hangzhou, PR China
    Search for articles by this author
  • Author Footnotes
    e Present address: Department of Food Science and Nutrition, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, PR China.

      Summary

      Background & aims

      Results from randomized controlled trials (RCT) of B vitamin supplementation on risk of cardiovascular disease (CVD) were inconclusive. The aim of the present study was to systematically review the effects of B vitamin supplementation on plasma homocysteine (Hcy), cardiovascular and all-cause mortality in RCT.

      Methods

      RCT publications on the effect of B vitamin supplementation on plasma Hcy, cardiovascular and all-cause mortality were searched from PubMed and web of science database. Data were independently abstracted by 2 investigators using a standardized protocol. The results were pooled with a fixed-effects model using Stata software.

      Results

      Data from 19 studies including 47921participants were analyzed using a fixed-effects model. The overall relative risks with 95% confidence intervals of outcomes for patients treated with B vitamin supplementation compared with placebo were 0.98 (0.94–1.03) for CVD, 0.98 (0.92–1.05) for coronary heart disease (CHD), 0.97 (0.90–1.05) for myocardial infarction (MI), 0.88 (0.82–0.95) for stroke, and 0.97 (0.91–1.02) for cardiovascular death, 0.99 (0.95–1.04) for all-cause mortality. Blood Hcy levels were decreased in all included RCTs.

      Conclusions

      B vitamin supplementation has a significant protective effect on stroke, but none on the risk of CVD, MI, CHD, cardiovascular death, or all-cause mortality.

      Keywords

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