Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes

Published:January 12, 2011DOI:


      Background & aims

      This study was undertaken to assess magnesium intake and magnesium status in patients with type 2 diabetes, and to identify the parameters that best predict alterations in fasting glucose and plasma magnesium.


      A cross-sectional study was carried out in patients with type 2 diabetes (n = 51; 53.6 ± 10.5 y) selected within the inclusion factors, at the University Hospital Onofre Lopes. Magnesium intake was assessed by three 24-h recalls. Urine, plasma and erythrocytes magnesium, fasting and 2-h postprandial glucose, HbA1, microalbuminuria, proteinuria, and serum and urine creatinine were measured.


      Mean magnesium intake (9.37 ± 1.76 mmol/d), urine magnesium (2.80 ± 1.51 mmol/d), plasma magnesium (0.71 ± 0.08 mmol/L) and erythrocyte magnesium (1.92 ± 0.23 mmol/L) levels were low. Seventy-seven percent of participants presented one or more magnesium status parameters below the cut-off points of 3.00 mmol/L for urine, 0.75 mmol/L for plasma and 1.65 mmol/L for erythrocytes. Subjects presented poor blood glucose control with fasting glucose of 8.1 ± 3.7 mmol/L, 2-h postprandial glucose of 11.1 ± 5.1 mmol/L, and HbA1 of 11.4 ± 3.0%. The parameters that influenced fasting glucose were urine, plasma and dietary magnesium, while plasma magnesium was influenced by creatinine clearance.


      Magnesium status was influenced by kidney depuration and was altered in patients with type 2 diabetes, and magnesium showed to play an important role in blood glucose control.



      HUOL (University Hospital Onofre Lopes), BMI (body mass index), WC (waist circumference), CCr (creatinine clearance), HbA1 (glycated hemoglobin), BDS (Brazilian Diabetes Society), D (difference between the observed average intake by each subject), SDD (standard deviation of D), EAR (estimated average requirement)
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        • Topf J.M.
        • Murray P.T.
        Hypomagnesemia and hypermagnesemia.
        Rev Endocr Metab Disord. 2003; 4: 195-206
        • Takaya J.
        • Higashino H.
        • Kobayashi Y.
        Intracellular magnesium and insulin resistance.
        Magnes Res. 2004; 17: 126-136
        • American Diabetes Association
        Nutrition recommendations and interventions for diabetes.
        Diabetes Care. 2008; 31: S61-S78
        • Sales C.H.
        • Pedrosa L.F.C.
        Magnesium and diabetes mellitus: their relation.
        Clin Nutr. 2006; 25: 554-562
        • Kao W.H.L.
        • Folsom A.R.
        • Javier Nieto F.
        • Mo J.-P.
        • Watson R.L.
        • Brancati F.L.
        Serum and dietary magnesium and the risk for type 2 diabetes mellitus: the atherosclerosis risk in communities study.
        Arch Intern Med. 1999; 159: 2151-2159
        • Lopez-Riadura R.
        • Willett W.C.
        • Rimm E.B.
        • Liu S.
        • Stampfer M.J.
        • Manson J.E.
        • et al.
        Magnesium intake and risk of type 2 diabetes in men and women.
        Diabetes Care. 2004; 27: 134-140
        • van Dam R.M.
        • Hu F.B.
        • Rosenberg L.
        • Krishnan S.
        • Palmer J.R.
        Dietary calcium and magnesium, major food sources, and risk of type 2 diabetes in U.S. black women.
        Diabetes Care. 2006; 29: 2238-2243
        • Villegas R.
        • Gao Y.T.
        • Dai G.Q.
        • Yang G.
        • Cai H.
        • Li H.
        • et al.
        Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai women’s health study.
        Am J Clin Nutr. 2009; 89: 1059-1067
        • Kim D.J.
        • Xun P.
        • Liu K.
        • Loria C.
        • Yokota K.
        • Jacobs Jr., D.R.
        • et al.
        Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes.
        Diabetes Care. 2010;
        • Nanri A.
        • Mizoue T.
        • Noda M.
        • Takahashi Y.
        • Kirii K.
        • Inoue M.
        • et al.
        Magnesium intake and type II diabetes in Japanese men and women: the Japan Public Health Center-based prospective study.
        Eur J Clin Nutr. 2010; 64: 1244-1247
        • Suárez A.
        • Pulido N.
        • Casla A.
        • Casanova B.
        • Arrieta F.J.
        • Rovira A.
        Impaired tyrosine-kinase activity of muscle insulin receptors from hypomagnesaemic rats.
        Diabetologia. 1995; 38: 1262-1270
        • Mayer-Davis E.J.
        • Nichols M.
        • Liese A.D.
        • Bell R.A.
        • Dabelea D.M.
        • Johansen J.M.
        • SEARCH for Diabetes in Youth Study Group
        • et al.
        Dietary intake among youth with diabetes: the SEARCH for diabetes in youth study.
        J Am Diet Assoc. 2006; 106: 689-697
        • Pitt S.
        • May K.
        • Colman P.
        • Wraight P.
        Deficiencies in nutritional intake in patients admitted with diabetes-related foot complications.
        Nutr Diet. 2007; 64: 186-191
        • Ma J.
        • Folsom A.R.
        • Melnick S.L.
        • Eckfeldt J.H.
        • Sharrett A.R.
        • Nabulsi A.A.
        • et al.
        Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: the ARIC study.
        J Clin Epidemiol. 1995; 48: 927-940
        • Pham P.C.
        • Pham P.M.
        • Pham P.A.
        • Pham S.V.
        • Pham H.V.
        • Miller J.M.
        • et al.
        Lower serum magnesium levels are associated with more rapid decline of renal function in patients with diabetes mellitus type 2.
        Clin Nephrol. 2005; 63: 429-436
        • Prabodh S.
        • Prakash D.S.R.S.
        • Sudhakar G.
        • Chowdary N.V.S.
        • Desai V.
        • Shekhar R.
        Status of copper and magnesium levels in diabetic nephropathy cases: a case-control study from South India.
        Biol Trace Elem Res. 2010;
        • Pham P.C.
        • Pham P.M.
        • Pham P.T.
        • Pham S.V.
        • Pham P.A.
        • Pham P.T.
        The link between lower serum magnesium and kidney function in patients with diabetes mellitus type 2 deserves a closer look.
        Clin Nephrol. 2009; 71: 375-379
        • Lima M.L.
        • Pousada J.
        • Barbosa C.
        • Cruz T.
        Deficiência de magnésio e resistência à insulina em pacientes com diabetes mellitus tipo 2.
        Arq Bras Endocrinol Metabol. 2005; 49: 959-963
        • Paula F.J.A.
        • Lanna C.M.M.
        • Shuhama T.
        • Foss M.C.
        Effect of metabolic control on parathyroid hormone secretion in diabetic patients.
        Braz J Med Biol Res. 2001; 34: 1139-1145
        • Sociedade Brasileira de Diabetes
        Tratamento e Acompanhamento do Diabetes Mellitus. Diretrizes da Sociedade Brasileira de Diabetes.
        Diagraphic, Rio de Janeiro2007
        • Sales C.H.
        • Setaro L.
        • Rocha V.S.
        • Colli C.
        Magnésio plasmático e urinário: validação de métodos de análise.
        Braz J Pharm Sci. 2008; 44: 57
      1. Tietz N.W. Clinical guide to laboratory tests. 3rd ed. WB Saunders, Philadelphia1995
        • Food and Nutrition Board, Institute of Medicine
        in: Food and Nutrition Board, Institute of Medicine Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. National Academy Press, Washington1997: 190-249
        • Food and Nutrition Board, Institute of Medicine
        Using dietary reference intakes for nutrient assessment of individuals.
        in: Food and Nutrition Board, Institute of Medicine Dietary reference intakes: applications in dietary assessment. National Academy Press, Washington2000: 45-69
        • Willett W.C.
        • Howe G.R.
        • Kushi L.H.
        Adjustment for total energy intake in epidemiologic studies.
        Am J Clin Nutr. 1997; 65: 1220S-1228S
        • National Research Council
        • Coordinating Committee on Evaluation of Food Consumption Surveys
        • Subcommittee on Criteria for Dietary Evaluation
        Nutrient adequacy: assessment using food consumption surveys.
        National Academy Press, Washington1986
        • Dewitte K.
        • Dhondt A.
        • Giri M.
        • Stöckl D.
        • Rottiers R.
        • Lameire N.
        • et al.
        Differences in serum ionized and total magnesium values during chronic renal failure between nondiabetic and diabetic patients. A cross-sectional study.
        Diabetes Care. 2004; 27: 2503-2505
        • Corsonello A.
        • Ientile R.
        • Buemi M.
        • Cucinotta D.
        • Mauro V.N.
        • Macaione S.
        • et al.
        Serum ionized magnesium levels in type 2 diabetic patients with microalbuminuria or clinical proteinuria.
        Am J Nephrol. 2000; 20: 187-192
        • Sabatier M.
        • Pont F.
        • Arnaud M.J.
        • Turnlund J.R.
        A compartmental model of magnesium metabolism in healthy men based on two stable isotope tracers.
        Am J Physiol Regul Integr Comp Physiol. 2003; 285: R656-663