The effect of a controlled 8-week metabolic ward based lysine supplementation on muscle function, insulin sensitivity and leucine kinetics in young men

Published:April 05, 2012DOI:


      Background & aims

      The 2007 FAO/WHO/UNU lysine requirement is 30 mgkg−1d−1. Developing country populations may be at risk of lysine deficiency, with effects on muscle and its function. The effect of an 8 wk lysine supplementation diet on muscle mass and function was assessed.


      Healthy, under and well-nourished men were studied before and after 8 wk, during which low (n=20) and high (n=20) lysine diets were consumed. The low lysine diets (∼25 and ∼40 mgkg−1d−1 for under and well-nourished respectively) were based on the subjects’ habitual lysine intake, while the high lysine diet supplied 80 mgkg−1d−1. Anthropometry, muscle function, insulin sensitivity (IS) and leucine kinetics were measured before and after the experimental period.


      The high lysine diet had a small positive effect (about +7.5%) on muscle strength, but no effect on other parameters. Over the 8 wk period in the whole group, the change in muscle strength correlated with the change in muscle mass (r=0.5, P=0.001), while the change in muscle mass correlated with the change in IS (r=0.3, P=0.04), but there were no intake specific differences.


      Over an 8 wk controlled feeding period, an intake of 80 mglysinekg−1d−1 had a small positive effect on muscle strength, but no other effects.



      ALST (Appendicular lean soft tissue), GDR (Glucose disposal rate), HEC (Hyperinsulinemic Euglycemic Clamp), IAA (Indispensable amino acids), IS (Insulin Sensitivity), KIC (α-ketoisocaproate), MVC (Maximal voluntary contraction), NOLD (Non-oxidative leucine disposal), %BF (Percent Body fat)
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