Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: A randomized clinical trial

  • Gemma Chiva-Blanch
    Affiliations
    Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

    CIBER CB06/03 Fisiopatología de la Obesidad y la Nutrición, (CIBERobn) and RETIC RD06/0045, Spain
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  • Mireia Urpi-Sarda
    Affiliations
    Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

    CIBER CB06/03 Fisiopatología de la Obesidad y la Nutrición, (CIBERobn) and RETIC RD06/0045, Spain
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  • Emilio Ros
    Affiliations
    CIBER CB06/03 Fisiopatología de la Obesidad y la Nutrición, (CIBERobn) and RETIC RD06/0045, Spain
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  • Palmira Valderas-Martinez
    Affiliations
    Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

    CIBER CB06/03 Fisiopatología de la Obesidad y la Nutrición, (CIBERobn) and RETIC RD06/0045, Spain
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  • Rosa Casas
    Affiliations
    Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

    CIBER CB06/03 Fisiopatología de la Obesidad y la Nutrición, (CIBERobn) and RETIC RD06/0045, Spain
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  • Sara Arranz
    Affiliations
    Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

    CIBER CB06/03 Fisiopatología de la Obesidad y la Nutrición, (CIBERobn) and RETIC RD06/0045, Spain
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  • Marisa Guillén
    Affiliations
    Department of Preventive and Public Health, School of Medicine, University of Valencia, Valencia, Spain
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  • Rosa M. Lamuela-Raventós
    Affiliations
    CIBER CB06/03 Fisiopatología de la Obesidad y la Nutrición, (CIBERobn) and RETIC RD06/0045, Spain

    Nutrition and Food Science Department, XaRTA, INSA, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain
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  • Rafael Llorach
    Affiliations
    Nutrition and Food Science Department, XaRTA, INSA, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain

    INGENIO-CONSOLIDER Program, Fun-c-food CSD2007-06, Barcelona, Spain
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  • Cristina Andres-Lacueva
    Affiliations
    Nutrition and Food Science Department, XaRTA, INSA, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain

    INGENIO-CONSOLIDER Program, Fun-c-food CSD2007-06, Barcelona, Spain
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  • Ramon Estruch
    Correspondence
    Corresponding author. Department of Internal Medicine, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain. Tel.: +34 932275400x2233; fax: +34 93 2279365.
    Affiliations
    Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

    CIBER CB06/03 Fisiopatología de la Obesidad y la Nutrición, (CIBERobn) and RETIC RD06/0045, Spain
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Published:September 05, 2012DOI:https://doi.org/10.1016/j.clnu.2012.08.022

      Summary

      Background & aims

      Epidemiological data suggest that moderate red wine consumption reduces cardiovascular mortality and the incidence of diabetes. However, whether these effects are due to ethanol or to non-alcoholic components of red wine still remains unknown. The aim of the present study was to compare the effects of moderate consumption of red wine, dealcoholized red wine, and gin on glucose metabolism and the lipid profile.

      Methods

      Sixty-seven men at high cardiovascular risk were randomized in a crossover trial. After a run-in period, all received each of red wine (30 g alcohol/d), the equivalent amount of dealcoholized red wine, and gin (30 g alcohol/d) for 4 week periods, in a randomized order. Fasting plasma glucose and insulin, homeostasis model assessment of insulin resistance (HOMA-IR), plasma lipoproteins, apolipoproteins and adipokines were determined at baseline and after each intervention.

      Results

      Fasting glucose remained constant throughout the study, while mean adjusted plasma insulin and HOMA-IR decreased after red wine and dealcoholized red wine. HDL cholesterol, Apolipoprotein A-I and A-II increased after red wine and gin. Lipoprotein(a) decreased after the red wine intervention.

      Conclusions

      These results support a beneficial effect of the non-alcoholic fraction of red wine (mainly polyphenols) on insulin resistance, conferring greater protective effects on cardiovascular disease to red wine than other alcoholic beverages.
      www.isrctn.org: ISRCTN88720134.

      Keywords

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      References

        • Ronksley P.E.
        • Brien S.E.
        • Turner B.J.
        • Mukamal K.J.
        • Ghali W.A.
        Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis.
        BMJ. 2011; 342: d671
        • Baliunas D.O.
        • Taylor B.J.
        • Irving H.
        • Roerecke M.
        • Patra J.
        • Mohapatra S.
        • et al.
        Alcohol as a risk factor for type 2 diabetes: a systematic review and meta-analysis.
        Diabetes Care. 2009; 32: 2123-2132
        • Koppes L.L.J.
        • Dekker J.M.
        • Hendriks H.F.J.
        • Bouter L.M.
        • Heine R.J.
        Moderate alcohol consumption lowers the risk of type 2 diabetes: a meta-analysis of prospective observational studies.
        Diabetes Care. 2005; 28: 719-725
        • Wannamethee S.G.
        • Camargo Jr., C.A.
        • Manson J.E.
        • Willett W.C.
        • Rimm E.B.
        Alcohol drinking patterns and risk of type 2 diabetes mellitus among younger women.
        Arch Intern Med. 2003; 163: 1329-1336
        • Brien S.E.
        • Ronksley P.E.
        • Turner B.J.
        • Mukamal K.J.
        • Ghali W.A.
        Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies.
        BMJ. 2011; 342: d636
        • von Eckardstein A.
        • Sibler R.A.
        Possible contributions of lipoproteins and cholesterol to the pathogenesis of diabetes mellitus type 2.
        Curr Opin Lipidol. 2011; 22: 26-32
        • Reaven G.M.
        The insulin resistance syndrome.
        Curr Atheroscler Rep. 2003; 5: 364-371
        • Davies M.J.
        • Baer D.J.
        • Judd J.T.
        • Brown E.D.
        • Campbell W.S.
        • Taylor P.R.
        Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: a randomized controlled trial.
        JAMA. 2002; 287: 2559-2562
        • Napoli R.
        • Cozzolino D.
        • Guardasole V.
        • Angelini V.
        • Zarra E.
        • Matarazzo M.
        • et al.
        Red wine consumption improves insulin resistance but not endothelial function in type 2 diabetic patients.
        Metabolism. 2005; 54: 306-313
        • Cordain L.
        • Melby C.L.
        • Hamamoto A.E.
        • O'Neill D.S.
        • Cornier M.A.
        • Barakat H.A.
        • et al.
        Influence of moderate chronic wine consumption on insulin sensitivity and other correlates of syndrome X in moderately obese women.
        Metab Clin Exp. 2000; 49: 1473-1478
        • Sierksma A.
        • Patel H.
        • Ouchi N.
        • Kihara S.
        • Funahashi T.
        • Heine R.J.
        • et al.
        Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor-alpha, and insulin sensitivity.
        Diabetes Care. 2004; 27: 184-189
        • Beulens J.W.J.
        • van Beers R.M.
        • Stolk R.P.
        • Schaafsma G.
        • Hendriks H.F.J.
        The effect of moderate alcohol consumption on fat distribution and adipocytokines.
        Obesity (Silver Spring). 2006; 14: 60-66
        • Naissides M.
        • Mamo J.C.L.
        • James A.P.
        • Pal S.
        The effect of chronic consumption of red wine on cardiovascular disease risk factors in postmenopausal women.
        Atherosclerosis. 2006; 185: 438-445
        • Kim S.H.
        • Abbasi F.
        • Lamendola C.
        • Reaven G.M.
        Effect of moderate alcoholic beverage consumption on insulin sensitivity in insulin-resistant, nondiabetic individuals.
        Metabolism. 2009; 58: 387-392
        • Costanzo S.
        • Di Castelnuovo A.
        • Donati M.B.
        • Iacoviello L.
        • de Gaetano G.
        Wine, beer or spirit drinking in relation to fatal and non-fatal cardiovascular events: a meta-analysis.
        Eur J Epidemiol. 2011; 26: 833-850
        • Zern T.L.
        • Wood R.J.
        • Greene C.
        • West K.L.
        • Liu Y.
        • Aggarwal D.
        • et al.
        Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress.
        J Nutr. 2005; 135: 1911-1917
        • Castilla P.
        • Echarri R.
        • Dávalos A.
        • Cerrato F.
        • Ortega H.
        • Teruel J.L.
        • et al.
        Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects.
        Am J Clin Nutr. 2006; 84: 252-262
        • Chiva-Blanch G.
        • Urpi-Sarda M.
        • Llorach R.
        • Rotches-Ribalta M.
        • Guillén M.
        • Casas R.
        • et al.
        Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial.
        Am J Clin Nutr. 2012; 95: 326-334
        • Matthews D.R.
        • Hosker J.P.
        • Rudenski A.S.
        • Naylor B.A.
        • Treacher D.F.
        • Turner R.C.
        Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.
        Diabetologia. 1985; 28: 412-419
        • Zamora-Ros R.
        • Urpí-Sardà M.
        • Lamuela-Raventós R.M.
        • Estruch R.
        • Martínez-González M.A.
        • Bulló M.
        • et al.
        Resveratrol metabolites in urine as a biomarker of wine intake in free-living subjects: the PREDIMED Study.
        Free Radic Biol Med. 2009; 46: 1562-1566
        • Urpi-Sarda M.
        • Zamora-Ros R.
        • Lamuela-Raventos R.
        • Cherubini A.
        • Jauregui O.
        • de la Torre R.
        • et al.
        HPLC-tandem mass spectrometric method to characterize resveratrol metabolism in humans.
        Clin Chem. 2007; 53: 292-299
        • Nordestgaard B.G.
        • Chapman M.J.
        • Ray K.
        • Borén J.
        • Andreotti F.
        • Watts G.F.
        • et al.
        European Atherosclerosis Society Consensus Panel. Lipoprotein(a) as a cardiovascular risk factor: current status.
        Eur Heart J. 2010; 31: 2844-2853
        • Avellone G.
        • Di Garbo V.
        • Campisi D.
        • De Simone R.
        • Raneli G.
        • Scaglione R.
        • et al.
        Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis.
        Eur J Clin Nutr. 2006; 60: 41-47
        • Estruch R.
        • Sacanella E.
        • Mota F.
        • Chiva-Blanch G.
        • Antúnez E.
        • Casals E.
        • et al.
        Moderate consumption of red wine, but not gin, decreases erythrocyte superoxide dismutase activity: a randomised cross-over trial.
        Nutr Metab Cardiovasc Dis. 2011; 21: 46-53
        • Sharpe P.C.
        • McGrath L.T.
        • McClean E.
        • Young I.S.
        • Archbold G.P.
        Effect of red wine consumption on lipoprotein (a) and other risk factors for atherosclerosis.
        QJM. 1995; 88: 101-108
        • Paassilta M.
        • Kervinen K.
        • Rantala A.O.
        • Savolainen M.J.
        • Lilja M.
        • Reunanen A.
        • et al.
        Social alcohol consumption and low Lp(a) lipoprotein concentrations in middle aged Finnish men: population based study.
        BMJ. 1998; 316: 594-595
        • Kanner J.
        • Gorelik S.
        • Roman S.
        • Kohen R.
        Protection by polyphenols of postprandial human plasma and low-density lipoprotein modification: the stomach as a bioreactor.
        J Agric Food Chem. 2012; 60: 8790-8796
        • Gibson A.
        • Woodside J.V.
        • Young I.S.
        • Sharpe P.C.
        • Mercer C.
        • Patterson C.C.
        • et al.
        Alcohol increases homocysteine and reduces B vitamin concentration in healthy male volunteers -a randomized, crossover intervention study.
        Q J Med. 2008; 101: 881-887
        • Marcucci R.
        • Gori A.M.
        • Bertuccioli M.
        • Gensini G.F.
        • Abbate R.
        In vivo effect of Chianti red wine on tissue factor, tissue factor pathway inhibitor and homocysteine levels.
        Thromb Haemostat. 2005; 94: 689-690
        • Lemos C.
        • Peters G.J.
        • Jansen G.
        • Martel F.
        • Calhau C.
        Modulation of folate uptake in cultured human colon adenocarcinoma Caco-2 cells by dietary compounds.
        Eur J Nutr. 2007; 46: 329-336