Recent advances in complementary and replacement therapy with nutraceuticals in combating gastrointestinal illnesses

  • Author Footnotes
    1 Equal contribution first authors.
    ,
    Author Footnotes
    2 School of Chemical and Biomedical Engineering, Nanyang Food Science and Technology Initiative, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore
    Natasha Yang
    Footnotes
    1 Equal contribution first authors.
    2 School of Chemical and Biomedical Engineering, Nanyang Food Science and Technology Initiative, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore
    Affiliations
    School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 693798, Singapore
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  • Author Footnotes
    1 Equal contribution first authors.
    Kaarunya Sampathkumar
    Footnotes
    1 Equal contribution first authors.
    Affiliations
    School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 693798, Singapore
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  • Say Chye Joachim Loo
    Correspondence
    Corresponding author. School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 693798, Singapore.
    Affiliations
    School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 693798, Singapore

    Singapore Centre on Environmental Life Sciences Engineering, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore
    Search for articles by this author
  • Author Footnotes
    1 Equal contribution first authors.
    2 School of Chemical and Biomedical Engineering, Nanyang Food Science and Technology Initiative, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore
Published:August 30, 2016DOI:https://doi.org/10.1016/j.clnu.2016.08.020

      Summary

      The digestive system provides nourishment to the whole body. Disorders in this system would result in many associated illnesses as the body is deprived of essential nutrients. Gastrointestinal diseases, in particular, gastric ulceration, inflammatory bowel diseases and colorectal cancer have become more prevalent in all population age groups. While this can be attributed to diet and lifestyle changes, the measures to combat these illnesses with conventional drugs is losing popularity owing to the harsh side effects, drug resistance and lack of patient compliance. The focus of this review is to endorse promising nutraceutical dietary components such as phytosterols, polyphenols, anthocyanins and polyunsaturated fatty acids and their synergistic value, in combination with conventional management of key gastrointestinal diseases. As most of these nutraceuticals are labile compounds, the need for protection and delivery using a carrier system is stressed and the methods for targeting to specific parts of the gastrointestinal tract are discussed. A section has also been devoted to perspectives on co-encapsulation methods of drugs and nutraceuticals using different particle systems. Multilayered carrier systems like double layered and core shell particles have been proposed as an exemplary system to co-encapsulate both drugs and nutrients while keeping them segregated.

      Keywords

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