Antioxidant response to artichoke leaf extract supplementation in metabolic syndrome: A double-blind placebo-controlled randomized clinical trial

  • Khatereh Rezazadeh
    Talented Students Center, Student Research Committee, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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  • Soodabeh Aliashrafi
    Student Research Committee, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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  • Mohammad Asghari-Jafarabadi
    Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Department of Statistics and Epidemiology, School of Health, Tabriz University of Medical Sciences, Tabriz, Iran
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  • Mehrangiz Ebrahimi-Mameghani
    Corresponding author. Nutrition Research Center, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Attar Neyshaboori Av., Golghasht St., Tabriz, Iran. Tel.: +98 041 33357581; fax: +98 041 33344731.
    Nutrition Research Center, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Published:March 23, 2017DOI:



      Oxidative stress is associated with most components and complications of Metabolic Syndrome (MetS). Artichoke Leaf Extract (ALE) has demonstrated anti-oxidant properties in both laboratory and animal studies.


      This study was designed to examine the effects of ALE on oxidative stress indices in patients with MetS.


      In the current double-blind placebo-controlled randomized clinical trial, 80 patients with MetS were randomly allocated to either “ALE group” (received 1800 mg ALE as four tablets per day) or “Placebo group” (received placebo containing cornstarch, lactose and avicel as four tablets per day) for 12 weeks. Serum levels of malondialdehyde (MDA), total antioxidant capacity (TAC), oxidized-LDL (ox-LDL), red blood cell glutathione peroxidase (GPx) and superoxidase dismutase (SOD), as well as dietary intakes were assessed at baseline and at the end of the study.


      A total number of 68 patients completed the study (ALE group = 33; placebo group = 35). Dietary intakes of energy, macronutrients, and micronutrients were not significantly different between two groups throughout the trial, with the exception of zinc (p < 0.05). The concentration of ox-LDL decreased significantly in ALE group in comparison to the placebo group (−266.8 ± 615.9 vs −129.5 ± 591.2 ng/L; p < 0.05). However, no significant inter- and intra-group changes in MDA, SOD, GPx, and TAC concentrations were observed.


      ALE decreased serum ox-LDL level in patients with MetS, with no beneficial effects on other antioxidant indices.

      Clinical trial registration number




      MetS (Metabolic syndrome), ALE (Artichoke leaf extract), HDL-C (High density lipoprotein cholesterol), FBS (Fasting blood sugar), WC (Waist circumference), TG (Triglyceride), DBP (Diastolic blood pressure), SBP (Systolic blood pressure), TAC (Total antioxidant capacity), MDA (Malondialdehyde), GPx (Glutathione peroxidase), SOD (Superoxidase dismutase), Ox-LDL (Oxidized low density lipoprotein)
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