Processed red meat intake and risk of COPD: A systematic review and dose-response meta-analysis of prospective cohort studies

  • Asma Salari-Moghaddam
    Affiliations
    Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
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  • Alireza Milajerdi
    Affiliations
    Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
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  • Bagher Larijani
    Correspondence
    Corresponding author. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Fax: +98 21 88220037 8.
    Affiliations
    Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
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  • Ahmad Esmaillzadeh
    Correspondence
    Corresponding author. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, P.O. Box 14155-6117, Iran. Fax: +98 21 88984861.
    Affiliations
    Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

    Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Food Security Research Center, Department of Community Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran
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      Summary

      Background & aims

      No earlier study has summarized findings from previous publications on processed red meat intake and risk of Chronic Obstructive Pulmonary Disease (COPD). This systematic review and meta-analysis was conducted to examine the association between processed red meat intake and COPD risk.

      Methods

      We searched in PubMed/Medline, ISI Web of Knowledge, Scopus, EMBASE and Google Scholar up to April 2018 to identify relevant studies. Prospective cohort studies that considered processed red meat as the exposure variable and COPD as the main outcome variable or as one of the outcomes were included in the systematic review. Publications in which hazard ratios (HRs) were reported as effect size were included in the meta-analysis. Finally, five cohort studies were considered in this systematic review and meta-analysis.

      Results

      In total, 289,952 participants, including 8338 subjects with COPD, aged ≥27 years were included in the meta-analysis. These studies were from Sweden and the US. Linear dose response meta-analysis revealed that each 50 gr/week increase in processed red meat intake was associated with 8% higher risk of COPD (HR: 1.08; 95% CI: 1.03, 1.13). There was an evidence of non-linear association between processed red meat intake and risk of COPD (P < 0.001).

      Conclusions

      In this systematic review and meta-analysis, we found a significant positive association between processed red meat intake and risk of COPD.

      PROSPERO registration number

      CRD42017077971.

      Keywords

      Abbreviations:

      COPD (Chronic obstructive pulmonary disease), HR (Hazard ratio), CI (Confidence interval), NOS (Newcastle-Ottawa scale), SE (Standard error), FFQ (Food frequency questionnaire), GLST (Generalized least squares trend estimation)
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