Reply - Letter to the editor: Methodological issues on açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study

Published:December 03, 2021DOI:https://doi.org/10.1016/j.clnu.2021.12.002
      Thank you for forwarding the letter by Soltani-Kermanshahi [
      • Soltani-Kermanshahi M.
      Methodological issues on Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study.
      ]. We would also like to thank Soltani-Kermanshahi for his interest in reading our work and for pointing out that “Although the results of the study are very interesting, it seems that several statistical and methodological issues should be considered when interpreting the results”, such as washout period (definition of four weeks) and statistical analysis (normality test and test of equality for carryover effects) in our published original article [
      • de Liz S.
      • Cardoso A.L.
      • Copetti C.L.K.
      • de Fragas Hinnig P.
      • Vieira F.G.
      • da Silva E.L.
      • et al.
      Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study.
      ].

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      References

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      1. Estimate carryover effect in clinical trial crossover designs. David Shen1 and Zaizai Lu2.1 WCI, Inc.; 2AstraZeneca Pharmaceuticals. https://www.lexjansen.com/pharmasug/2006/Posters/PO16.pdf.

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